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Table 5 Classification of Angioedema

From: WAO Guideline for the Management of Hereditary Angioedema

Bradykinin-Induced AE Mast Cell Mediator-Induced AE  
C1-INH Deficiency/Defect C1-INH Normal IgE Mediated Non-IgE Mediated Unknown Mediator Idiopathic AE
Inherited Acquired Inherited Acquired Angioedema with anaphylaxis Urticaria Angioedema with urticaria --
HAE-1 AAE HAE-3 ACE-I -- -- --
HAE-2       
  1. AAE, acquired angioedema due to C1 inhibitor deficiency; ACE-I, angiotensin-converting enzyme-induced angioedema; AE, angioedema; HAE-1, hereditary angioedema due to C1 inhibitor deficiency; HAE-2, hereditary angioedema due to C1 Inhibitor defect; HAE-3, hereditary angioedema with normal C1 inhibitor levels.