TY - JOUR AU - Sahiner, Umit M. AU - Birben, Esra AU - Erzurum, Serpil AU - Sackesen, Cansin AU - Kalayci, Omer PY - 2011 DA - 2011/12/01 TI - Oxidative Stress in Asthma JO - World Allergy Organization Journal SP - 151 EP - 158 VL - 4 IS - 10 AB - Asthma is a chronic inflammatory lung disease that results in airflow limitation, hyperreactivity, and airway remodeling. There is strong evidence that an imbalance between the reducing and oxidizing systems favoring a more oxidative state is present in asthma. Endogenous and exogenous reactive oxygen species, such as superoxide anion, hydroxyl radical, hypohalite radical, and hydrogen peroxide, and reactive nitrogen species, such as nitric oxide, peroxynitrite, and nitrite, play a major role in the airway inflammation and are determinants of asthma severity. Asthma is also associated with decreased antioxidant defenses, such as superoxide dismutase, catalase, and glutathione. In this review, we will summarize the current knowledge and discuss the current and future strategies for the modulation of oxidative stress in asthma. SN - 1939-4551 UR - https://doi.org/10.1097/WOX.0b013e318232389e DO - 10.1097/WOX.0b013e318232389e ID - Sahiner2011 ER -