Interleukin-13 Signaling and Its Role in Asthma

Table 1 IL-13 Single-Nucleotide Polymorphisms (SNP) Associated With Asthma

Gene	SNP(s)/SNP ID#	SNP Associated Phenotype	Race Background	PValue if Available	Reference
IL13	Arg130Gln	Atopy	Multi-center	0.01	([93])
		Total eosinophil, total serum IgE level	Childhood asthmatics with mild to moderate asthma	0.0442
	Arg130Gln (= G4257A)	Atopic dermatitis	Japanese aged 11-61	0.043	([94])
	Arg130Gln/IL4C-589T	Atopy	Canadian children with family	0.006	([95])
	Haplotype		history of asthma
	Arg130Gln	Atopy	Iceland chart review	0.67	([96])
	Arg130Gln	Late wheeze age 6	Dutch children	0.007	([97])
	Arg130Gln	Asthma	British young	0.017 B	([98])
		No association with IgE levels	Japanese young adults	0.026 J
	Arg130Gln	Total serum IgE	German children	0.005	([99])
	- 1112C/T			0.0002
	- 1112C/T rs1800925	Severe RSV infection asthma	German children < 2 hospitalized for RSV	0.026	([100])
	- 1112C/T	Asthma	Dutch	.005 asthma	([101])
		BHR		.003 BHR
		+ Skin test		.03 + ST
	- 646A/G	FEV1 postbronchodilator	African American	0.009	([102])
IL4Rα	Gln551Arg	Atopic asthma	Meta analysis combo adult + children	OR 1.6; P = 0.004	([103])

ISSN: 1939-4551