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Figure 1 | World Allergy Organization Journal

Figure 1

From: Soluble Guanylyl Cyclase is Reduced in Airway Smooth Muscle Cells From a Murine Model of Allergic Asthma

Figure 1

Airway smooth muscle histologic studies from OVA-sensitized and control rats. The panels (A) and (B) represent the typical tracheal tissue of the CONTROL rats group showing a thin layer of smooth muscle (SMt) located between the edges of the hyaline cartilage ring (HC) and it is enclosed by connective tissue (CT) with the adventitia. The SM is bound to perichondrial tissue (p) through bundles of smooth muscle cells (SMC). These SMC cells have elongated shape, eosinophilic cytoplasm, and basophilic nucleus. The panels (C) and (D) represent the tracheal wall of OVA rats, having a characteristic layered arrangement of the trachea, because the epithelium (Hep) is thickened with hyperplasia of caliciform cells (mL), basal membrane (Bm), lamina propia (LP), and tunic submucosa (SM). Increased cellular connective tissue and mononuclear cell infiltration (*), and formation of blood vessels (BV), are shown. In the layer of SM an inflammatory infiltrate around the SMC is also observed. Sections were stained with hematoxylin & eosin. Magnification: × 100 (A, C) and × 400 (B, D).

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