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Figure 4 | World Allergy Organization Journal

Figure 4

From: Anti-Ids in Allergy: Timeliness of a Classic Concept

Figure 4

Mechanisms of anti-idiotypic antibodies on effector cells. Mediator release of effector cells (E) is triggered by cross-linkage of 2 receptor-bound IgE either via (A) recognition of the antigen or (B) the anti-id. (C) Effector cell inhibition is achieved by binding of the anti-id to its specific idiotype within a polyclonal response. (D) Cross-linkage of FcεRI and the inhibitory FcγRIIb receptor via an anti-idiotypic IgG antibody also inhibits degranulation.

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World Allergy Organization Journal

ISSN: 1939-4551

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