Table 1 Examples and Characteristics of Biologic Agents Potentially Relevant to Asthma and Allergic Diseases
| Â | Target | Biologic Agent | Manufacturer | Composition | Reference |
|---|---|---|---|---|---|
Cell surface | Â | Â | Â | Â | Â |
| Â | CD4 | Keliximab | SmithKline Beecham Pharmaceuticals | Chimeric IgG1 monoclonal antibody | 9,10 |
| Â | CD23 | IDEC-152 | Biogen IDEC | Chimeric IgG1 monoclonal antibody | 11 |
| Â | CD25 | Daclizumab | Roche | Humanized IgG1 monoclonal antibody | 12 |
|  | IL-4Rα | Pitrakinra | Aerovance | 15 kDa recombinant human IL-4 variant that is an antagonist of both IL-4 and IL-13 receptor binding | 21 |
| Â | Â | AMG 317 | Amgen | Fully human IgG2 monoclonal antibody | 22 |
| Â | IL-5R | MEDI-563 | MedImmune | Humanized IgG1 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity function | 32 |
Soluble | Â | Â | Â | Â | Â |
| Â | IgE | Omalizumab | Genentech and Novartis | Humanized IgG1 monoclonal antibody | 14 |
| Â | IL-4 | Nuvance | Immunex | Soluble IL-4 receptor | 3 |
| Â | IL-4 | Pascolizumab | GlaxoSmithKline and Protein Design Labs | Humanized IgG1 monoclonal antibody | 5 |
| Â | IL-5 | Mepolizumab | GlaxoSmithKline | Humanized IgG1 monoclonal antibody | 23 |
| Â | IL-9 | MEDI-528 | MedImmune | Humanized IgG1 monoclonal antibody | 27 |
|  | TNFα | Golimumab | Centocor/Schering-Plough | Fully human IgG1 monoclonal antibody | 8 |
| Â | Â | Infliximab | Centocor Ortho Biotech | Chimeric IgG1 monoclonal antibody | 7 |
| Â | Â | Etanercept | Immunex/Amgen | IgG1 fusion protein containing the extracellular domain of the p75 TNF receptor | 6 |