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Figure 1 | World Allergy Organization Journal

Figure 1

From: Pathological Mechanisms of Skin Homing T Cells in Atopic Dermatitis

Figure 1

During cutaneous inflammation in AD, CLA+ T cell-selective chemokines are produced that allow continuous migration of skin-reactive CLA+ T cells to inflamed lesions (step 1). Once in the inflamed skin, CLA+ T cells are activated and a portion of the memory T cells return to the blood through the thoracic duct (step 2). CLA+ T cells present in the blood present features of recent activation and spontaneous production of cytokines and can migrate back to inflamed skin.

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