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Table 2 Selected SLIT and OIT Studies

From: Food Allergy: Present and Future Management

 

Allergen Received (No. of Subjects)

Length of Therapy

Efficacy

Sublingual

   

   Enrique et al. [25]

Hazelnut (11)

8-12 weeks

Five (45%) of 11 reached highest dose (20 g) in food challenge.

   Bird et al. (ongoing)

Peanut (7)

30 months

At 4 months, no significant change in peanut-specific IgE, IgG, IgG4, or skin prick wheal diameter.

Oral

   

   Patriarca et al. [26]

Varied (24)

18 months

Desensitization was successful in 45 (77%) of 58 treatments.

   Buchanan et al. [27]

Egg (7)

24 months

Four (57%) of 7 passed food challenge with 14.7 g of egg at conclusion of therapy; 2 passed second challenge 3-4 months later.

   Staden et al. [28]

Cow's milk or egg (45)

11-59 months

Nine of 25 children (36%) showed tolerance in the treatment and in the control group, 7 of 20 children (35%) were tolerant.

   Skripak et al. [29]

Cow's milk (19)

5-6 months

Eight out of 19 (42%) passed food challenge with 8 g of milk. Treatment subjects who underwent a posttreatment challenge had significant median increase in threshold dose.

   Jones et al. [30]

Peanut (29)

18 months

Twenty-seven of 29 (93%) passed food challenge to 3.9 g of peanut.

   Varshney et al. (ongoing)

Peanut (27)

1 year

All treatment subjects that have undergone food challenges have tolerated 5 g of peanut.

  1. Adapted from Burks et al. Oral tolerance, food allergy, and immunotherapy: implications for future treatment. J Allergy Clin Immunol. 2008;121:1348.