| Allergen Received (No. of Subjects) | Length of Therapy | Efficacy |
---|---|---|---|
Sublingual | Â | Â | Â |
   Enrique et al. [25] | Hazelnut (11) | 8-12 weeks | Five (45%) of 11 reached highest dose (20 g) in food challenge. |
   Bird et al. (ongoing) | Peanut (7) | 30 months | At 4 months, no significant change in peanut-specific IgE, IgG, IgG4, or skin prick wheal diameter. |
Oral | Â | Â | Â |
   Patriarca et al. [26] | Varied (24) | 18 months | Desensitization was successful in 45 (77%) of 58 treatments. |
   Buchanan et al. [27] | Egg (7) | 24 months | Four (57%) of 7 passed food challenge with 14.7 g of egg at conclusion of therapy; 2 passed second challenge 3-4 months later. |
   Staden et al. [28] | Cow's milk or egg (45) | 11-59 months | Nine of 25 children (36%) showed tolerance in the treatment and in the control group, 7 of 20 children (35%) were tolerant. |
   Skripak et al. [29] | Cow's milk (19) | 5-6 months | Eight out of 19 (42%) passed food challenge with 8 g of milk. Treatment subjects who underwent a posttreatment challenge had significant median increase in threshold dose. |
   Jones et al. [30] | Peanut (29) | 18 months | Twenty-seven of 29 (93%) passed food challenge to 3.9 g of peanut. |
   Varshney et al. (ongoing) | Peanut (27) | 1 year | All treatment subjects that have undergone food challenges have tolerated 5 g of peanut. |