Figure 2

Activation of the extrinsic pathway of the coagulation cascade by eosinophil-derived tissue factor in patients with chronic urticaria. Eosinophils produce and store tissue factor (blue triangles), and rapidly transfer it to the cell membrane during activation. Activation of the coagulation cascade and fibrinolysis in patients with chronic urticaria is demonstrated by the increased plasma levels of the prothrombin fragment F1+2 and D-dimer (indicated by red arrows).