From: The Role of Antihistamines in the Treatment of Vasomotor Rhinitis
H1 Antagonist | H1 Receptor (nM) | H2 Receptor (nM) | H3 Receptor (nM) |
---|---|---|---|
Ketotifen | 1.3 | 1155 | 2277 |
Emedastine | 1.3 | 49,067 | 12,430 |
Desloratadine | 4 | ND | ND |
Cetirizine | 6.3 | ND | ND |
Azelastine | 6.8 | ND | ND |
Epinastine | 9.8* | 4030* | ND |
Diphenhydramine | 12.5 | 1600 | 25,000 |
Olopatadine | 32 | 100,000 | 79,400 |
Loratadine | 35 | ND | ND |
Levocabastine | 56 | 23,500 | 4597 |
Fexofenadine | 83 | ND | ND |
Pyrilamine | 0.8 | 9510 | 1016 |
Chlorpheniramine | 1.4 | 7980 | 3103 |
Pheniramine | 34 | 14,567 | 10,567 |
Antazoline | 38 | 44,433 | 42,400 |
Ranitidine | 46,100 | 187 | 10,537 |
Cimetidine | 6190 | 2377 | 20,750 |
Thioperamide | 280,000 | 57,967 | 1.1 |
Methylhistamine | 138,000 | 72,100 | 1.4 |
Histamine | 180,000 | 18,350 | 4.5 |