The Treatment of Vasomotor Rhinitis With Intranasal Corticosteroids

Table 2 Effects of Corticosteroids on Inflammatory Cells

Cells Affected	Corticosteroid Effect
T-lymphocytes	Reduction of circulating cell number, apoptosis
	Inhibition of:
	T-lymphocyte activation
	IL-2 production
	IL-2 receptor generation
	IL-4 production
	Antigen-driven proliferation
Eosinophils	Reduction of circulating cell number, apoptosis
	Reduction of epithelial and mucosal cell counts
	Reduction of cell influx in late-phase response
	Inhibition of IL-4 and IL-5-mediated cell survival
Mast cells/basophils	Reduction of circulating cell counts
	Reduction of cell influx in late-phase response
	Reduction of mast cell-derived mediators after challenge
	Reduction of histamine content and release
Neutrophils	Reduction of cell influx after challenge
Macrophages/monocytes	Reduction of circulating cell counts
	Inhibition of release of:
	IL-1
	Interferon-gamma
	TNF-alpha
	GM-CSF

ISSN: 1939-4551