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Table 2 Effects of Corticosteroids on Inflammatory Cells

From: The Treatment of Vasomotor Rhinitis With Intranasal Corticosteroids

Cells Affected Corticosteroid Effect
T-lymphocytes Reduction of circulating cell number, apoptosis
  Inhibition of:
  T-lymphocyte activation
  IL-2 production
  IL-2 receptor generation
  IL-4 production
  Antigen-driven proliferation
Eosinophils Reduction of circulating cell number, apoptosis
  Reduction of epithelial and mucosal cell counts
  Reduction of cell influx in late-phase response
  Inhibition of IL-4 and IL-5-mediated cell survival
Mast cells/basophils Reduction of circulating cell counts
  Reduction of cell influx in late-phase response
  Reduction of mast cell-derived mediators after challenge
  Reduction of histamine content and release
Neutrophils Reduction of cell influx after challenge
Macrophages/monocytes Reduction of circulating cell counts
  Inhibition of release of:
  IL-1
  Interferon-gamma
  TNF-alpha
  GM-CSF