Table 1 Summarizing Findings of Current Neuroimaging Studies
From: Recent Progress in Unraveling Central Nervous System Processing of Itch Sensation
Healthy Volunteers | Atopic Patients | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Hsieh et al[12]PET | Drzezga et al[15]PET | Mochizuki et al[16]PET | Schneider et al[20]PET | Walter et al[17]fMRI | Leknes et al[19]fMRI | Valet et al[14]fMRI | Mochizuki et al[18]fMRI | Herde et al[22]fMRI | Leknes et al[19]fMRI | Schneider et al[20]PET | |
Neuroimaging analysis | Subtraction | Correlation | Subtraction | Correlation | Correlation | Correlation | Subtraction | Correlation | Subtraction | Correlation | Correlation |
Itch induction | Intracutaneous injection | Skin prick model | Iontophoresis | Iontophoresis | Skin prick model | Skin prick model | Skin prick model | Iontophoresis | Intracutaneous microdialysis | Skin prick model | Iontophoresis |
Itch stimulus | Histamine | Histamine | Histamine | Histamine | Histamine | Histamine | Histamine | Histamine | Histamine and codeine | Histamine | Histamine |
Brain region | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
Primary somatosensory cortex (BA 1-3) | -- | I, C | -- | C | -- | -- | C- | -- | C | C | -- |
Somatosensory association/parietal cortex (BA 5, 7) | -- | I, C | I | C | -- | -- | -- | -- | C | -- | -- |
Primary motor cortex (BA 4) | -- | C | -- | -- | -- | -- | -- | -- | -- | C | -- |
Premotor and presupplementary motor cortex (BA 6) | I, C | I, C | I | C | -- | -- | I | I | I, C | C | I, C |
Cerebellum | I, C | -- | -- | -- | C | -- | -- | -- | I, C | -- | I, C |
Insular cortex (BA 13, 14) | -- | C | -- | -- | -- | I, C | C | C | I, C | -- | I |
Cingulate cortex (BA 23, 24, 25, 32) | C | I, C | C | C | C | I, C | I- | C | I, C | I, C | -- |
Prefrontal cortex (BA 9) | I, C | C | -- | I | -- | -- | -- | -- | I, C | -- | I |
Frontopolar and orbitofrontal area (BA 10-12) | -- | C | -- | -- | I, C | -- | I-, C- | I | C | I, C | I |
Inferior parietal and dorsolateral prefrontal cortex (BA 45, 46) | -- | C | I, C | -- | -- | -- | I, C | -- | I, C | -- | -- |
Temporal gyrus (BA 20-22) | -- | -- | -- | -- | C | -- | -- | -- | I, C | -- | -- |
Temporal lobe/Wernicke area (BA 38-40) | -- | -- | I | -- | -- | -- | I, C | -- | I, C | C | C |
Thalamus | -- | -- | C | -- | -- | I, C | I, C | -- | I, C | I, C | C |
Basal ganglia | -- | -- | -- | -- | -- | I | -- | I | I, C | I, C | I |