Figure 2
From: Recent Progress in Unraveling Central Nervous System Processing of Itch Sensation
The increase of histamine-induced itch during the first 8 seconds of the 25°C stimulation periods (as compared with saline) is associated with an increase (red) and decrease (blue) of activation in various brain structures subserving sensory, emotional, cognitive, and motivational aspects of itch processing. As an example, the averaged relative fMRI BOLD signal of all subjects during 20 seconds of the 25°C stimulation period is presented: for the pre-SMA region with increased and the cingulate cortex with decreased activation in comparison with saline. DLPFC indicates dorsolateral prefrontal cortex; IPC, inferior parietal cortex; MFC, medial frontal cortex; OFC, orbitofrontal cortex; R, right side of the brain. From Valet et al[14].