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Table 1 Omalizumab: Summary of Effects on Airway Inflammation

From: Anti-Immunoglobulin E Therapy

Decreases free serum IgE

Decreases expression of FcεRI (on mast cells, basophils, dendritic cells, and monocytes)

Decreases eosinophils (serum, sputum, bronchial biopsies)

Decreases B lymphocytes

Decreases antigen-induced mediator release from basophils and mast cells

Decreases circulating IL-13

Decreases airway inflammation

Decreases FeNO

  1. Adapted from Stokes and Casale [29].
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World Allergy Organization Journal

ISSN: 1939-4551

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