Figure 1
From: Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation
Structure of BCL6. The BCL6 gene encodes a 92- to 98-kd nuclear phosphoprotein that contains the BTB/POZ domain in the NH2-terminal region and Krüppel-type zinc finger motifs in the COOH-terminal region. The NH2-terminal half of BCL6 can bind to SMRT and recruit the SMRT/histone deacetylase complex to silencer regions of target genes to repress the expression of these genes. Because the BCL-6 zinc-fingers bind DNA in a sequence-specific manner, BCL6 can function as a sequence-specific transcriptional repressor.