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Figure 4 | World Allergy Organization Journal

Figure 4

From: Angioedema

Figure 4

Diagrammatic representation of the plasma kinin-forming cascade indicating steps inhibitable by C1 INH. All functions of factor XIIa and kallikrein are affected. Further digestion of factor XIIa (lower figure) by kallikrein and plasmin generates factor XII fragment (XIIf), which is an initiator of the complement cascade. Both factor XIIf and C1 are inhibited by C1 INH.

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