This article is one of a series of international consensus documents developed from the International Drug Allergy Symposium held at the Joint Congress of the American Academy of Allergy, Asthma & Immunology/W...
The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food all...
Authors: J. Andrew Bird, Mario Sánchez-Borges, Ignacio J. Ansotegui, Motohiro Ebisawa and José Antonio Ortega Martell
The severe forms of asthma represent a major burden, because of severity of symptoms, costs and impact on everyday life. Recently, Mepolizumab (MEP) was approved and marketed for the treatment of hypereosinoph...
Authors: Diego Bagnasco, Manlio Milanese, Giovanni Rolla, Carlo Lombardi, Caterina Bucca, Enrico Heffler, Giorgio Walter Canonica and Giovanni Passalacqua
TRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age.
Authors: Gustavo F. Wandalsen, Renata G. Dias, Herberto J. Chong-Neto, Nelson Rosário, Lillian Moraes, Neusa F. Wandalsen, Décio Medeiros, Ana Caroline Della Bianca, Marilyn Urrutia-Pereira, Jennifer Avila, Patrícia P. Jorge and Dirceu Solé
The prevalence of allergic diseases, such as asthma, allergic rhinitis, eczema and food allergy, has been increasing worldwide, as shown in a large number of studies, including the International Study of Asthm...
Authors: Evelyn Xiu Ling Loo, Lamony Jian Ming Chew, Atiqa Binte Zulkifli, Le Duc Huy Ta, I-Chun Kuo, Anne Goh, Oon Hoe Teoh, Hugo Van Bever, Peter D. Gluckman, Fabian Yap, Kok Hian Tan, Yap Seng Chong, Bee Wah Lee and Lynette Pei-chi Shek
Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranula...
Authors: Takashi Fujimura, Ayane Hori, Hideto Torii, Shinsuke Kishida, Yoshinori Matsuura and Seiji Kawamoto
Data are limited regarding the effectiveness of omalizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Our aim was to evaluate the clinical and functional effectiveness of omalizumab...
Authors: Zeynep Celebi Sozener, Begum Gorgulu, Dilsad Mungan, Betul Ayse Sin, Zeynep Misirligil, Omur Aydin and Sevim Bavbek
In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and...
Authors: Olga Smoldovskaya, Guzel Feyzkhanova, Sergei Voloshin, Alla Arefieva, Antonina Chubarova, Ludmila Pavlushkina, Tatiana Filatova, Eugenia Antonova, Elena Timofeeva, Veronika Butvilovskaya, Yuri Lysov, Alexander Zasedatelev and Alla Rubina
Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on a...
Authors: Rajan Merchant, Stanley J. Szefler, Bruce G. Bender, Michael Tuffli, Meredith A. Barrett, Rahul Gondalia, Leanne Kaye, David Van Sickle and David A. Stempel
There is a high prevalence of allergies in Germany, with approximately 20% of the population having at least one allergy and only about 10% of these being treated adequately. We conducted a cross-sectional stu...
Authors: Danielle Boehmer, Barbara Schuster, Julia Krause, Ulf Darsow, Tilo Biedermann and Alexander Zink
Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America (...
Authors: M. Maurer, K. Houghton, C. Costa, F. Dabove, L. F. Ensina, A. Giménez-Arnau, G. Guillet, G. N. Konstantinou, M. Labrador-Horrillo, H. Lapeere, R. Meshkova, E. A. Pastorello, M. Velásquez-Lopera, L. M. Tamayo Quijano, C. Vestergaard and N. Chapman-Rothe
Asthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions...
Authors: Alina Gherasim, Ahn Dao and Jonathan A Bernstein
Asthma is one of the most common chronic respiratory conditions worldwide. Asthma-related economic burden has been reported in Latin America, but knowledge about its economic impact to the Colombian health car...
Authors: Álvaro Flórez-Tanus, Devian Parra, Josefina Zakzuk, Luis Caraballo and Nelson Alvis-Guzmán
The burden of disease of food allergy is increasing worldwide. The standard of management is allergen avoidance and symptomatic treatment. Probiotics have been proposed to be beneficial for treatment and preve...
Authors: Carol Stephanie C. Tan-Lim and Natasha Ann R. Esteban-Ipac
Data on the prevalence of perennial versus seasonal allergic asthma in Italy are lacking; moreover, there is limited evidence on the effect of omalizumab on patient-reported outcomes in Italian patients with s...
Authors: Giorgio Walter Canonica, Paola Rottoli, Caterina Bucca, Maria Cristina Zappa, Giovanni Michetti, Bruno Macciocchi, Cristiano Caruso, Pierachille Santus, Marta Bartezaghi and Laura Rigoni
In recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cy...
Authors: Linda Zhu, Christina E. Ciaccio and Thomas B. Casale
The aim of this study was to evaluate the positivity rates of atopy patch tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis in patients with respiratory diseases such as ast...
Authors: Ingrid Pimentel Cunha Magalhães de Souza Lima, Beatriz Julião Aarestrup, Eduardo Magalhães de Souza Lima, Marina Cunha de Souza Lima, Eduardo Cunha de Souza Lima and Fernando Monteiro Aarestrup
Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a po...
Authors: Katharina Bastl, Maximilian Kmenta, Markus Berger and Uwe Berger
Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is know...
Authors: Tsung-Chieh Yao, Ann Chen Wu, Ya-Wen Huang, Jiu-Yao Wang and Hui-Ju Tsai
So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2)...
Authors: Franziska Roth-Walter, René Schmutz, Nadine Mothes-Luksch, Patrick Lemell, Petra Zieglmayer, René Zieglmayer and Erika Jensen-Jarolim
Classical allergy diagnostic workup “from symptoms to molecules” comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagno...
Authors: N. Mothes-Luksch, G. Jordakieva, L. Hinterhölzl, A. N. Jensen, P. K. Hallmann, M. Kundi and E. Jensen-Jarolim
Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of an...
Authors: Taghreed Abunada, Maryam Ali Al-Nesf, Lukman Thalib, Rana Kurdi, Sally Khalil, Wessam ElKassem, Hassan M. Mobayed and Hatem Zayed
Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal s...
Authors: Galateja Jordakieva and Erika Jensen-Jarolim
Although asthma cannot be cured, appropriate management can ensure adequate control of the disease, prevent disease progression and even reverse the illness, enabling people to enjoy good quality of life. Pred...
This review article aims to present the epidemiology and associated risk factors of allergic rhinitis (AR) in Asia. AR-related literature published on Asia was systematically reviewed and the associated risk f...
Web-based surveys (WBS) are increasingly applied in epidemiological studies as an appealing alternative to traditional survey methods. Rapid data collection, reduced expenditure and ease of access to large pop...
Authors: Thu T. K. Le, Thuy T. B. Tran, Huong T. M. Ho, An T. L. Vu and Andreas L. Lopata
Collecting data on the localization of users is a key issue for the MASK (Mobile Airways Sentinel networK: the Allergy Diary) App. Data anonymization is a method of sanitization for privacy. The European Commi...
Authors: D. Samreth, S. Arnavielhe, F. Ingenrieth, A. Bedbrook, G. L. Onorato, R. Murray, R. Almeida, M. A. Mizani, J. Fonseca, E. Costa, J. Malva, M. Morais-Almeida, A. M. Pereira, A. Todo-Bom, E. Menditto, C. Stellato…
The approaches to the diagnosis and treatment of chronic spontaneous urticaria (CSU) differ in various parts of the world. We sought to determine the adherence to international and national urticaria guideline...
Authors: Pavel Kolkhir, Dmitry Pogorelov, Razvigor Darlenski, Marco Caminati, Luciana Kase Tanno, Duy Le Pham, Alexei Gonzalez-Estrada, Darío Antolín-Amérigo, Ves Dimov, Karsten Weller, Mario Sánchez-Borges, Ignacio Ansotegui and Marcus Maurer
Type 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recentl...
Authors: Marco Caminati, Duy Le Pham, Diego Bagnasco and Giorgio Walter Canonica
Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustain...
The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default...
Authors: Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro and Lamia Dahdah
Randomized controlled trials of prenatal omega (ω-3) long chain polyunsaturated fatty acid (LCPUFA) supplementation are suggestive of some protective effects on allergic sensitization and symptoms of allergic ...
Authors: K. P. Best, T. R. Sullivan, D. J. Palmer, M. Gold, J. Martin, D. Kennedy and M. Makrides
Atopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowdin...
Authors: Jens Christian Richter, Kristina Jakobsson, Tahir Taj and Anna Oudin
Authors: Mario Sánchez-Borges, Bryan L. Martin, Antonella M. Muraro, Robert A. Wood, Ioana O. Agache, Ignacio J. Ansotegui, Thomas B. Casale, Thomas A. Fleisher, Peter W. Hellings, Nikolaos G. Papadopoulos, David B. Peden, James L. Sublett, Stephen A. Tilles and Lanny Rosenwasser
Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the ...
Authors: Enrico Heffler, Francesca Puggioni, Silvia Peveri, Marcello Montagni, Giorgio Walter Canonica and Giovanni Melioli
Allergic and non-allergic rhinitis cause a lot of symptoms in everyday life. To decrease the burden more information of the preventable risk factors is needed. We assessed prevalence and risk factors for chron...
Authors: Hanna Hisinger-Mölkänen, Päivi Piirilä, Tari Haahtela, Anssi Sovijärvi and Paula Pallasaho
Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and appropriate therapy are essential. This update and revision of the global guideline for HAE provides up-to-date consensus recomm...
Authors: Marcus Maurer, Markus Magerl, Ignacio Ansotegui, Emel Aygören-Pürsün, Stephen Betschel, Konrad Bork, Tom Bowen, Henrik Balle Boysen, Henriette Farkas, Anete S. Grumach, Michihiro Hide, Constance Katelaris, Richard Lockey, Hilary Longhurst, William R. Lumry, Inmaculada Martinez-Saguer…
Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FP...
Authors: Stephanie A. Leonard, Valentina Pecora, Alessandro Giovanni Fiocchi and Anna Nowak-Wegrzyn
In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. ...
The 2010 Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines are the only Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines for cow’s milk aller...
Authors: Alessandro Fiocchi, Holger Schunemann, Ignacio Ansotegui, Amal Assa’ad, Sami Bahna, Roberto Berni Canani, Martin Bozzola, Lamia Dahdah, Christophe Dupont, Motohiro Ebisawa, Elena Galli, Haiqi Li, Rose Kamenwa, Gideon Lack, Alberto Martelli, Ruby Pawankar…
The purpose of this study was to identify chronic urticaria (CU) etiologies and treatment modalities in Ecuador. We propose that the sample distribution fits the expected one, and that there is an association ...
Authors: I. Cherrez Ojeda, E. Vanegas, M. Felix, V. Mata, S. Cherrez, D. Simancas-Racines, L. Greiding, J. Cano, A. Cherrez and Juan Carlos Calderon
There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung. These result fro...
Authors: Iris Koper, Karin Hufnagl and Rainer Ehmann
Sex hormone allergy as a clinical syndrome has been known for almost a century. Due to the diversity of clinical presentation regarding symptoms and disease patterns, the optimal patient care represents an eno...
For years occupational allergies have been among the most frequently recorded occupational diseases, and both the skin as well as the respiratory tract may be affected. An estimated 9 to 15% of adult asthma is...
Authors: Monika Raulf, Thomas Brüning, Erika Jensen-Jarolim and Vera van Kampen
Gender-specific differences are evident in food intolerance and allergy. In this review, we will highlight and summarize the dissimilarities in prevalence of adverse food reactions, focusing on IgE-mediated fo...
Authors: Sheriene Moussa Afify and Isabella Pali-Schöll
Allergies need not only affect humans; this multifactorial and complex disease can also affect animals. Comparative allergology investigates the many similarities between the pathogenesis, clinics, diagnosis, ...
Authors: Ina Herrmann, Lukas Einhorn and Lucia Panakova
Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express sufficient lactase ...
Authors: Ralf G. Heine, Fawaz AlRefaee, Prashant Bachina, Julie C. De Leon, Lanlan Geng, Sitang Gong, José Armando Madrazo, Jarungchit Ngamphaiboon, Christina Ong and Jossie M. Rogacion
Authors: Giovanni Traina, Rocco Luigi Valluzzi, Vincenzo Fierro, Carla Riccardi, Maria Cristina Artesani, Andrea De Vuono, Alessandro Fiocchi, Alberto G. Martelli, Luis Alberto Ríos, Christian R. Alcocer, Elsy Navarrete, Blanca Estela Del Rio Navarro, Victor Gonzalez, Berenice Velasco, Herberth J. Perez Aviles, Roberto Jose Fernandez…
