Articles

Important questions in drug allergy and hypersensitivity: consensus papers from the 2018 AAAAI/WAO international drug allergy symposium

This article is one of a series of international consensus documents developed from the International Drug Allergy Symposium held at the Joint Congress of the American Academy of Allergy, Asthma & Immunology/W...

Authors: Pascal Demoly and Mariana Castells

Controversies in drug allergy: consensus documents from the world experts

Authors: Michael Schatz, Alessandro Fiocchi, Erika Jensen-Jarolim and Zuhair K. Ballas

Skin as an immune organ and clinical applications of skin-based immunotherapy

The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food all...

Authors: J. Andrew Bird, Mario Sánchez-Borges, Ignacio J. Ansotegui, Motohiro Ebisawa and José Antonio Ortega Martell

The North-Western Italian experience with anti IL-5 therapy amd comparison with regulatory trials

The severe forms of asthma represent a major burden, because of severity of symptoms, costs and impact on everyday life. Recently, Mepolizumab (MEP) was approved and marketed for the treatment of hypereosinoph...

Authors: Diego Bagnasco, Manlio Milanese, Giovanni Rolla, Carlo Lombardi, Caterina Bucca, Enrico Heffler, Giorgio Walter Canonica and Giovanni Passalacqua

Test for Respiratory and Asthma Control in Kids (TRACK): validation of the Portuguese version

TRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age.

Authors: Gustavo F. Wandalsen, Renata G. Dias, Herberto J. Chong-Neto, Nelson Rosário, Lillian Moraes, Neusa F. Wandalsen, Décio Medeiros, Ana Caroline Della Bianca, Marilyn Urrutia-Pereira, Jennifer Avila, Patrícia P. Jorge and Dirceu Solé

Comparison of microbiota and allergen profile in house dust from homes of allergic and non-allergic subjects- results from the GUSTO study

The prevalence of allergic diseases, such as asthma, allergic rhinitis, eczema and food allergy, has been increasing worldwide, as shown in a large number of studies, including the International Study of Asthm...

Authors: Evelyn Xiu Ling Loo, Lamony Jian Ming Chew, Atiqa Binte Zulkifli, Le Duc Huy Ta, I-Chun Kuo, Anne Goh, Oon Hoe Teoh, Hugo Van Bever, Peter D. Gluckman, Fabian Yap, Kok Hian Tan, Yap Seng Chong, Bee Wah Lee and Lynette Pei-chi Shek

Intake of a fermented plant product attenuates allergic symptoms without changing systemic immune responses in a mouse model of Japanese cedar pollinosis

Japanese cedar pollinosis (JCP) is one of the most prevalent allergies in Japan. Within the past few decades, many food factors have been demonstrated to suppress symptoms of pollinosis and mast cell degranula...

Authors: Takashi Fujimura, Ayane Hori, Hideto Torii, Shinsuke Kishida, Yoshinori Matsuura and Seiji Kawamoto

Omalizumab in the treatment of eosinophilic granulomatosis with polyangiitis (EGPA): single-center experience in 18 cases

Data are limited regarding the effectiveness of omalizumab in patients with eosinophilic granulomatosis with polyangiitis (EGPA). Our aim was to evaluate the clinical and functional effectiveness of omalizumab...

Authors: Zeynep Celebi Sozener, Begum Gorgulu, Dilsad Mungan, Betul Ayse Sin, Zeynep Misirligil, Omur Aydin and Sevim Bavbek

Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases

In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and...

Authors: Olga Smoldovskaya, Guzel Feyzkhanova, Sergei Voloshin, Alla Arefieva, Antonina Chubarova, Ludmila Pavlushkina, Tatiana Filatova, Eugenia Antonova, Elena Timofeeva, Veronika Butvilovskaya, Yuri Lysov, Alexander Zasedatelev and Alla Rubina

Impact of a digital health intervention on asthma resource utilization

Digital health interventions have been associated with reduced rescue inhaler use and improved controller medication adherence. This quality improvement project assessed the benefit of these interventions on a...

Authors: Rajan Merchant, Stanley J. Szefler, Bruce G. Bender, Michael Tuffli, Meredith A. Barrett, Rahul Gondalia, Leanne Kaye, David Van Sickle and David A. Stempel

Prevalence and treatment of allergies in rural areas of Bavaria, Germany: a cross-sectional study

There is a high prevalence of allergies in Germany, with approximately 20% of the population having at least one allergy and only about 10% of these being treated adequately. We conducted a cross-sectional stu...

Authors: Danielle Boehmer, Barbara Schuster, Julia Krause, Ulf Darsow, Tilo Biedermann and Alexander Zink

Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study

Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America (...

Authors: M. Maurer, K. Houghton, C. Costa, F. Dabove, L. F. Ensina, A. Giménez-Arnau, G. Guillet, G. N. Konstantinou, M. Labrador-Horrillo, H. Lapeere, R. Meshkova, E. A. Pastorello, M. Velásquez-Lopera, L. M. Tamayo Quijano, C. Vestergaard and N. Chapman-Rothe

Confounders of severe asthma: diagnoses to consider when asthma symptoms persist despite optimal therapy

Asthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions...

Authors: Alina Gherasim, Ahn Dao and Jonathan A Bernstein

Health care costs and resource utilization for different asthma severity stages in Colombia: a claims data analysis

Asthma is one of the most common chronic respiratory conditions worldwide. Asthma-related economic burden has been reported in Latin America, but knowledge about its economic impact to the Colombian health car...

Authors: Álvaro Flórez-Tanus, Devian Parra, Josefina Zakzuk, Luis Caraballo and Nelson Alvis-Guzmán

Probiotics as treatment for food allergies among pediatric patients: a meta-analysis

The burden of disease of food allergy is increasing worldwide. The standard of management is allergen avoidance and symptomatic treatment. Probiotics have been proposed to be beneficial for treatment and preve...

Authors: Carol Stephanie C. Tan-Lim and Natasha Ann R. Esteban-Ipac

Improvement of patient-reported outcomes in severe allergic asthma by omalizumab treatment: the real life observational PROXIMA study

Data on the prevalence of perennial versus seasonal allergic asthma in Italy are lacking; moreover, there is limited evidence on the effect of omalizumab on patient-reported outcomes in Italian patients with s...

Authors: Giorgio Walter Canonica, Paola Rottoli, Caterina Bucca, Maria Cristina Zappa, Giovanni Michetti, Bruno Macciocchi, Cristiano Caruso, Pierachille Santus, Marta Bartezaghi and Laura Rigoni

Potential new targets for drug development in severe asthma

In recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cy...

Authors: Linda Zhu, Christina E. Ciaccio and Thomas B. Casale

Brazilian experience with atopy patch tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis

The aim of this study was to evaluate the positivity rates of atopy patch tests for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis in patients with respiratory diseases such as ast...

Authors: Ingrid Pimentel Cunha Magalhães de Souza Lima, Beatriz Julião Aarestrup, Eduardo Magalhães de Souza Lima, Marina Cunha de Souza Lima, Eduardo Cunha de Souza Lima and Fernando Monteiro Aarestrup

The connection of pollen concentrations and crowd-sourced symptom data: new insights from daily and seasonal symptom load index data from 2013 to 2017 in Vienna

Online pollen diaries and mobile applications nowadays allow easy and fast documentation of pollen allergy symptoms. Such crowd-sourced symptom data provides insights into the development and the onset of a po...

Authors: Katharina Bastl, Maximilian Kmenta, Markus Berger and Uwe Berger

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001–2013

Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is know...

Authors: Tsung-Chieh Yao, Ann Chen Wu, Ya-Wen Huang, Jiu-Yao Wang and Hui-Ju Tsai

Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2)...

Authors: Franziska Roth-Walter, René Schmutz, Nadine Mothes-Luksch, Patrick Lemell, Petra Zieglmayer, René Zieglmayer and Erika Jensen-Jarolim

Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

Classical allergy diagnostic workup “from symptoms to molecules” comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagno...

Authors: N. Mothes-Luksch, G. Jordakieva, L. Hinterhölzl, A. N. Jensen, P. K. Hallmann, M. Kundi and E. Jensen-Jarolim

Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study

Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of an...

Authors: Taghreed Abunada, Maryam Ali Al-Nesf, Lukman Thalib, Rana Kurdi, Sally Khalil, Wessam ElKassem, Hassan M. Mobayed and Hatem Zayed

The impact of allergen exposure and specific immunotherapy on circulating blood cells in allergic rhinitis

Allergic rhinitis (AR) is an IgE-mediated inflammatory disease of the nasal mucosa with well described local immune responses during allergen exposure. The frequent association of AR with general extra-nasal s...

Authors: Galateja Jordakieva and Erika Jensen-Jarolim

Appropriateness of chronic asthma management and medication adherence in patients visiting ambulatory clinic of Gondar University Hospital: a cross-sectional study

Although asthma cannot be cured, appropriate management can ensure adequate control of the disease, prevent disease progression and even reverse the illness, enabling people to enjoy good quality of life. Pred...

Authors: Zelalem Tilahun Tesfaye, Nebeyu Tsegu Gebreselase and Boressa Adugna Horsa

Epidemiology of allergic rhinitis and associated risk factors in Asia

This review article aims to present the epidemiology and associated risk factors of allergic rhinitis (AR) in Asia. AR-related literature published on Asia was systematically reviewed and the associated risk f...

Authors: Sher Ney Chong and Fook Tim Chew

Prevalence of food allergy in Vietnam: comparison of web-based with traditional paper-based survey

Web-based surveys (WBS) are increasingly applied in epidemiological studies as an appealing alternative to traditional survey methods. Rapid data collection, reduced expenditure and ease of access to large pop...

Authors: Thu T. K. Le, Thuy T. B. Tran, Huong T. M. Ho, An T. L. Vu and Andreas L. Lopata

Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study

Collecting data on the localization of users is a key issue for the MASK (Mobile Airways Sentinel networK: the Allergy Diary) App. Data anonymization is a method of sanitization for privacy. The European Commi...

Authors: D. Samreth, S. Arnavielhe, F. Ingenrieth, A. Bedbrook, G. L. Onorato, R. Murray, R. Almeida, M. A. Mizani, J. Fonseca, E. Costa, J. Malva, M. Morais-Almeida, A. M. Pereira, A. Todo-Bom, E. Menditto, C. Stellato…

Management of chronic spontaneous urticaria: a worldwide perspective

The approaches to the diagnosis and treatment of chronic spontaneous urticaria (CSU) differ in various parts of the world. We sought to determine the adherence to international and national urticaria guideline...

Authors: Pavel Kolkhir, Dmitry Pogorelov, Razvigor Darlenski, Marco Caminati, Luciana Kase Tanno, Duy Le Pham, Alexei Gonzalez-Estrada, Darío Antolín-Amérigo, Ves Dimov, Karsten Weller, Mario Sánchez-Borges, Ignacio Ansotegui and Marcus Maurer

Type 2 immunity in asthma

Type 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recentl...

Authors: Marco Caminati, Duy Le Pham, Diego Bagnasco and Giorgio Walter Canonica

Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument

Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustain...

Authors: Wenyin Loh and Mimi L. K. Tang

Debates in Allergy Medicine: Does oral immunotherapy shorten the duration of milk and egg allergy? The pro argument

The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default...

Authors: Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro and Lamia Dahdah

Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial

Randomized controlled trials of prenatal omega (ω-3) long chain polyunsaturated fatty acid (LCPUFA) supplementation are suggestive of some protective effects on allergic sensitization and symptoms of allergic ...

Authors: K. P. Best, T. R. Sullivan, D. J. Palmer, M. Gold, J. Martin, D. Kennedy and M. Makrides

High burden of atopy in immigrant families in substandard apartments in Sweden – on the contribution of bad housing to poor health in vulnerable populations

Atopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowdin...

Authors: Jens Christian Richter, Kristina Jakobsson, Tahir Taj and Anna Oudin

The importance of allergic disease in public health: an iCAALL statement

Authors: Mario Sánchez-Borges, Bryan L. Martin, Antonella M. Muraro, Robert A. Wood, Ioana O. Agache, Ignacio J. Ansotegui, Thomas B. Casale, Thomas A. Fleisher, Peter W. Hellings, Nikolaos G. Papadopoulos, David B. Peden, James L. Sublett, Stephen A. Tilles and Lanny Rosenwasser

Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis

Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the ...

Authors: Enrico Heffler, Francesca Puggioni, Silvia Peveri, Marcello Montagni, Giorgio Walter Canonica and Giovanni Melioli

Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis

Allergic and non-allergic rhinitis cause a lot of symptoms in everyday life. To decrease the burden more information of the preventable risk factors is needed. We assessed prevalence and risk factors for chron...

Authors: Hanna Hisinger-Mölkänen, Päivi Piirilä, Tari Haahtela, Anssi Sovijärvi and Paula Pallasaho

The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update

Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and appropriate therapy are essential. This update and revision of the global guideline for HAE provides up-to-date consensus recomm...

Authors: Marcus Maurer, Markus Magerl, Ignacio Ansotegui, Emel Aygören-Pürsün, Stephen Betschel, Konrad Bork, Tom Bowen, Henrik Balle Boysen, Henriette Farkas, Anete S. Grumach, Michihiro Hide, Constance Katelaris, Richard Lockey, Hilary Longhurst, William R. Lumry, Inmaculada Martinez-Saguer…

Food protein-induced enterocolitis syndrome: a review of the new guidelines

Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FP...

Authors: Stephanie A. Leonard, Valentina Pecora, Alessandro Giovanni Fiocchi and Anna Nowak-Wegrzyn

Vespa crabro immunotherapy versus Vespula-venom immunotherapy in Vespa crabro allergy: a comparison study in field re-stings

In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. ...

Authors: Donatella Macchia, Gabriele Cortellini, Marina Mauro, Elisa Meucci, Oliviero Quercia, Mariangela Manfredi, Alessandro Massolo, Maurizio Valentini, Maurizio Severino and Giovanni Passalacqua

The global impact of the DRACMA guidelines cow’s milk allergy clinical practice

The 2010 Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines are the only Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines for cow’s milk aller...

Authors: Alessandro Fiocchi, Holger Schunemann, Ignacio Ansotegui, Amal Assa’ad, Sami Bahna, Roberto Berni Canani, Martin Bozzola, Lamia Dahdah, Christophe Dupont, Motohiro Ebisawa, Elena Galli, Haiqi Li, Rose Kamenwa, Gideon Lack, Alberto Martelli, Ruby Pawankar…

Etiology of chronic urticaria: the Ecuadorian experience

The purpose of this study was to identify chronic urticaria (CU) etiologies and treatment modalities in Ecuador. We propose that the sample distribution fits the expected one, and that there is an association ...

Authors: I. Cherrez Ojeda, E. Vanegas, M. Felix, V. Mata, S. Cherrez, D. Simancas-Racines, L. Greiding, J. Cano, A. Cherrez and Juan Carlos Calderon

Gender effects in allergology – Secondary publications and update

Authors: Erika Jensen-Jarolim

Gender aspects and influence of hormones on bronchial asthma – Secondary publication and update

There is good evidence for gender-specific differences in asthma regarding all affected areas, from intra- to extra-cellular mediators to the whole organ structure und functioning of the lung. These result fro...

Authors: Iris Koper, Karin Hufnagl and Rainer Ehmann

Sex hormone allergy: clinical aspects, causes and therapeutic strategies – Update and secondary publication

Sex hormone allergy as a clinical syndrome has been known for almost a century. Due to the diversity of clinical presentation regarding symptoms and disease patterns, the optimal patient care represents an eno...

Authors: E. Untersmayr, A. N. Jensen and K. Walch

Gender-related aspects in occupational allergies – Secondary publication and update

For years occupational allergies have been among the most frequently recorded occupational diseases, and both the skin as well as the respiratory tract may be affected. An estimated 9 to 15% of adult asthma is...

Authors: Monika Raulf, Thomas Brüning, Erika Jensen-Jarolim and Vera van Kampen

Adverse reactions to food: the female dominance – A secondary publication and update

Gender-specific differences are evident in food intolerance and allergy. In this review, we will highlight and summarize the dissimilarities in prevalence of adverse food reactions, focusing on IgE-mediated fo...

Authors: Sheriene Moussa Afify and Isabella Pali-Schöll

Gender aspects in allergies of pets – A secondary publication and update

Allergies need not only affect humans; this multifactorial and complex disease can also affect animals. Comparative allergology investigates the many similarities between the pathogenesis, clinics, diagnosis, ...

Authors: Ina Herrmann, Lukas Einhorn and Lucia Panakova

Lactose intolerance and gastrointestinal cow’s milk allergy in infants and children – common misconceptions revisited

Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express sufficient lactase ...

Authors: Ralf G. Heine, Fawaz AlRefaee, Prashant Bachina, Julie C. De Leon, Lanlan Geng, Sitang Gong, José Armando Madrazo, Jarungchit Ngamphaiboon, Christina Ong and Jossie M. Rogacion

Proceedings of the 2017 WAO Symposium on Hot Topics in Allergy: Pediatric & Regulatory Aspects

Authors: Giovanni Traina, Rocco Luigi Valluzzi, Vincenzo Fierro, Carla Riccardi, Maria Cristina Artesani, Andrea De Vuono, Alessandro Fiocchi, Alberto G. Martelli, Luis Alberto Ríos, Christian R. Alcocer, Elsy Navarrete, Blanca Estela Del Rio Navarro, Victor Gonzalez, Berenice Velasco, Herberth J. Perez Aviles, Roberto Jose Fernandez…