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Table 1 Demography and atopic status data from three of most representative studies on severe asthma

From: Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?

 

Enfumosa study

Tenor study

SARP Study

Study design/location

Cross-sectional European multicentre study (9 Countries)

U.S. Multicentre

Observational study

Observational cross-sectional multicentre study

(9 sites in U.S. and 1 site in U.K.)

Patients (N.) with severe asthma

163

2282 (48% OF TOTAL)

204

Age characteristics

Age range: 17-65 yrs

Mean age ± SD : 38.9 ± 20.92 yrs

Mean age ± SD: 41 ± 13 yrs

Sex

Sex ratio (F/M) : 4.4 / 1

Not reportedc

Females: 64%

≥1 Positive skin prick test

58%

(VS. 78% OF Controlled asthmatics)

-

71%

(VS. 85% of mild and 87% of moderate asthma)

Mean total serum IgE

109 KU/L-1, 95% CI: 85-139

106.6 IU/mla

2.0 ± 7.6b

References

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3

4

  1. aOverall, the TENOR study patients with severe asthma had elevated geometric mean IgE values compared with patients with moderate and mild asthma. IgE values for children and adolescents increased with asthma severity
  2. bTotal serum IgE (log)
  3. cOverall patients (mild/moderate/severe asthma): females : 2945 (62.2%); males : 1792 (37.8%)