Table 5 Some helminth immunomodulatory products
Name | Helminth | Effects |
|---|---|---|
Cystatin | A. vitae | Inhibition of antigenic processing. Suppression of Th2 inflammation in airway hypersensitivity models and Th1 driven responses in experimental colitis. Induction of IL-10 production. |
ES-62 | A. vitae | Decreases inflammation in rheumatoid arthritis model through IL-17 blockage. Inhibition of mast cell activation and allergic reactions in airway sensitization models. |
TGF-beta like factor | H. polygirus, B. malayi | Inhibition of airway inflammation, possibly through binding to mammalian TGF-beta receptor. |
SM-16 | Schistosoma spp. | Suppression of thioglycollate-induced peritoneal macrophage maturation. Prevention of classical macrophage activation. |
Galectin | T. leonine | Reduction of clinical manifestations of experimental colitis. Th1 and Th2 inhibition by increasing IL-10 and TGF-B production. |
PAS-1 | A. suum | Reduction of allergic responses in airway hypersensitivity models. It also increases IL-10 and TGF-beta production |