From: Off-label prescribing for allergic diseases in children
Category | Drug | Indication | Age lower limit | Maximum allowed dose | ||
---|---|---|---|---|---|---|
Europe | USA | Europe* | US# | |||
Nasal inhaled corticosteroids | Budesonide | Allergic Rhinitis | 6 years | 6 years | 400 μg/day | 400 μg/day |
Fluticasone furoate | 4 years | 4 years | 50 μg/day – 4 to 12 years | 200 μg/day | ||
 |  |  | 200 μg/day ≥ 12 years |  | ||
Mometasone | 6 years | 2 years | 100 μg/day | 100 μg/day -2 to 11 years; | ||
 |  |  |  |  |  | 200 μg/day ≥ 12 years |
Oral antihistamines | Cetirizine | Allergic rhinitis; Urticaria | 2 years | 6 months | 5 mg/day – 2 to 6 years; | 2.5 mg/day- 6 months to 1year |
 |  |  |  | 10 mg/day > 6 years | 5 mg/day- >1 year to 5 years | |
 |  |  |  |  | 10 mg ≥ 6 years | |
 | Levocetirizine | 2 years | 6 months | 2.5 mg/day – 2 to 6 years; | 1.25 mg 6 months to 5 years | |
 |  |  |  | 5 mg/day – older than 6 years | 2.5 mg- 6 years to 11 years | |
 |  |  |  |  | 5 mg ≥ 12 years | |
 | Loratadine | 2 years | 2 years | 5 mg/day – 2 to 6 years; | ||
 |  |  |  | 10 mg/day > 6 years | ||
 | Desloratadine | 12 months | 6 months | 1.25 mg/day – 1 to 5 years; | 1 mg – 6 to 11 months | |
 |  |  |  | 2.5 mg/day – 6 to 12 years; | 1.25 mg/day – 1 to 5 years; | |
 |  |  |  | 5 mg/day ≥ 12 years; | 2.5 mg/day – 6 to 11 years; | |
 |  |  |  |  | 5 mg/day ≥ 12 years | |
 | Fexofenadine |  | 6 years | 6 years | 60 mg/day – 6 to 11 years | 30 mg/day- 6 months to < 2 years |
 |  |  |  | 180 mg/day ≥ 12 years | 60 mg/day – 2 to 11 years | |
 |  |  |  |  | 180 mg/day ≥ 12 years | |
 | Diphenhydramine | 6 years | 2 years | 75 mg/day – 6 to 12 years; | 37.5 mg/day – 2 to 5 years | |
 |  |  |  | 150 mg/day > 12 years | 150 mg/day – 6 to 11 years | |
 |  |  |  |  | 300 mg/day ≥ 12 years | |
Topical immunomodulators | Pimecrolimus | Atopic Dermatitis | 2Â years | 2Â years | Twice daily, intermittent treatment 12 months | Twice daily, intermittent treatment 12 months |
 | Tacrolimus |  | 2 years | 2 years | 0.03%- 2 to 15 years | 0.03% – 2 to 15 years |
 |  |  |  |  | 0.1% ≥ 16 years | 0.1% ≥ 16 years |
 |  |  |  |  | (twice daily for 3 weeks then once daily, intermittent use) | (twice daily for intermittent use) |