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Figure 2 | World Allergy Organization Journal

Figure 2

From: Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

Figure 2

Pathways activated by TGF β to induce EMT. An idealilzed epithelial cell before and after EMT showing the canonical (smad) and non-canonical TGFβ intracellular signaling pathways. The TGFβ signaling is upstream of the master transcriptional regulators, snail (SNAI1/2), zebra (ZEB) and Twist (Twst) that induce transcriptional reprogramming and chromatin remodeling through histone modification. Stimulation of TGFβ pathways result in repression of ECad (CADH1) and upregulation of fibronectin (FIB), collagen 1 (Col1) and α-SMA in the epithelial cell. Known interconnections with the TNF-NFκB inflammatory response are diagrammed.

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World Allergy Organization Journal

ISSN: 1939-4551

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