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Figure 1 | World Allergy Organization Journal

Figure 1

From: Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

Figure 1

Schematic view of EMT in the airway. Shown is a segment of airway epithelium and homeostatic properties affected by type II EMT. The induction of type II EMT is modulated by growth factors released from the ECM and tissue resident leukocytes (eosinophils) and results in loss of adherens junctions (aj), loss of apical-basal polarity and disruption of mucosal barrier function, enhanced ECM deposition and dysregulated innate signaling. Also, there is suppression of innate immunity in some asthmatics but the link between EMT and suppression of innate immunity needs to be explored further. TGFβ, transforming growth factor beta; FGF, fibroblast growth factor; EGF, epithelial growth factor.

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World Allergy Organization Journal

ISSN: 1939-4551

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