Hereditary Angioedema Caused By C1-Esterase Inhibitor Deficiency: A Literature-Based Analysis and Clinical Commentary on Prophylaxis Treatment Strategies

Table 2 Common Adverse Events Associated With Attenuated Androgen Therapy*

Adverse Event	Prevalence Rate (%)	Reference(s)
Weight gain	14.3-60.0	[59], [60], [62], [70], [72], [74], [75]
Acne	4.8-22.0	[59], [62], [70], [72], [75], [76]
Virilization†	1.8-46.6	[59], [60], [62], [72], [75]
Menstrual irregularities	14.4-80.0	[59–62], [70], [72], [75], [76]
Headache/migraine	13.6-49.5	[59], [62], [74], [75]
Psychological abnormalities‡	9.4-16.0	[59], [62], [72]
Arterial hypertension	25.0-30.0	[70], [74]
Lipid abnormalities	27	[73], [75]
Hepatic disease/adenomas§	1.8-40.0	[59], [60], [62], [75]
Hematuria	13	[62]

*Includes data for danazol and stanozolol. Patients may have experienced more than 1 adverse event.
†Includes voice changes, increased hair growth, decrease in breast size, clitoral hypertrophy, increase in muscle mass, laryngeal prominence.
‡Includes depression, aggressiveness, fatigue, panic attacks, mood changes.
§Includes increase in pathological laboratory findings, including hepatic enzymes.

ISSN: 1939-4551