Table 1 Distinguishing Features Comparing AD-HIES With DIDS and TYK2 HIES
From: The Hyper-IgE Syndromes: Lessons in Nature, From Bench to Bedside
Clinical Finding | AD-HIES | DIDS AR-HIES | TYK2 AR-HIES |
|---|---|---|---|
Viral skin infections | - | +++ | ++ |
Pneumatoceles | ++ | - | - |
Recurrent pneumonia | ++ | ++ | ++ |
Sepsis mortality | + | +++ | +++ |
Facial dysmorphic features | +++ | - | - |
Primary tooth retention | +++ | - | - |
Scoliosis | ++ | - | - |
Neurologic manifestations | + | +++ | ++ |
Cerebral vascular abnormalities | + | ++ | ++ |
Food allergies | - | +++ | - |
Environmental allergies | - | ++ | Â |
Decreased IgM | - | ++ | - |
Atypical mycobacterial infections | - | - | ++ |
Malignancy | + | +++ | ? |
Lymphoma | + | + | ? |