Figure 1From: Pathological Mechanisms of Skin Homing T Cells in Atopic DermatitisDuring cutaneous inflammation in AD, CLA+ T cell-selective chemokines are produced that allow continuous migration of skin-reactive CLA+ T cells to inflamed lesions (step 1). Once in the inflamed skin, CLA+ T cells are activated and a portion of the memory T cells return to the blood through the thoracic duct (step 2). CLA+ T cells present in the blood present features of recent activation and spontaneous production of cytokines and can migrate back to inflamed skin.Back to article page