Table 4 H3 Receptor Antagonists
From: The Role of Antihistamines in the Treatment of Vasomotor Rhinitis
Receptor | H3 |
|---|---|
Signal conduction through | Gi/o |
Location of receptors | Mainly expressed on presynaptic nerves in the peripheral sympathetic adrenergic system and histaminergic nerves in the central nervous system. Receptors can be found in airways and gastrointestinal tract |
Chromosome location | 20q13.33 |
Signal conduction induces | Decreased cyclic AMP, induction MAP kinase |
Antagonists (reverse agonists) | None available clinically: Thioperamide, alobenpropit, and others Very little data regarding effect of H1 antagonists on the H3 receptor are available (13) |
Activities | Opposes bronchoconstriction and gastric acid; suppression of norepinephrine release at presynaptic nerve endings |
Nasal symptoms produced | Can produce nasal decongestion by blocking effect of histamine on adrenergic postsynaptic receptors |